Research

The University of Pittsburgh Department of Medicine is a formidable leader in cutting-edge research. Our basic scientists, clinical researchers, and clinicians work daily to make research discoveries that will positively impact the world’s healthcare.

Our numbers:

  • With 665 faculty, we are the largest department within the University of Pittsburgh School of Medicine.
  • Our NIH funding level is ranked in the top 10 nationally among other Departments of Internal Medicine.
  • The medical school’s NIH funding level ranks fifth in the nation.

Our scientists, physician-scientists, and clinicians do the advanced research that is changing people’s lives—and furthering our understanding of science. The papers they publish in high-impact journals … the grants and training awards they receive, including five new T32s in fiscal year 2015-16 … are all reflections of our investigators’ skill, dedication, and commitment.

Latest High-Impact Publications
JCI InsightUnexpected kidney-restricted role for IL-17 receptor signaling in defense against systemic Candida albicans infection.
Ramani K, Jawale CV, Verma AH, Coleman BM, Kolls JK, Biswas PS.
JCI Insight.2018 May 3;3(9). pii: 98241. doi: 10.1172/jci.insight.98241.
Nature ImmunologyIL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival.
Majumder S, Amatya N, Revu S, Jawale CV, Wu D, Rittenhouse N, Menk A, Kupul S, Du F, Raphael I, Bhattacharjee A, Siebenlist U, Hand TW, Delgoffe GM, Poholek AC, Gaffen SL, Biswas PS, McGeachy MJ.
Nat Immunol. 2019 May;20(5):534-545. doi: 10.1038/s41590-019-0367-4. Epub 2019 Apr 8.
PNASConcentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina.
Nmezi B, Xu J, Fu R, Armiger TJ, Rodriguez-Bey G, Powell JS, Ma H, Sullivan M, Tu Y, Chen NY, Young SG, Stolz DB, Dahl KN, Liu Y, Padiath QS.
Proc Natl Acad Sci U S A. 2019 Feb 14. pii: 201810070. doi: 10.1073/pnas.1810070116. [Epub ahead of print]
Cell MetabInhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by _-Catenin Mutations.
Adebayo Michael AO, Ko S, Tao J, Moghe A, Yang H, Xu M, Russell JO, Pradhan-Sundd T, Liu S, Singh S, Poddar M, Monga JS, Liu P, Oertel M, Ranganathan S, Singhi A, Rebouissou S, Zucman-Rossi J, Ribback S, Calvisi D, Qvartskhava N, Gšrg B, HŠussinger D, Chen X, Monga SP.
Cell Metab. 2019 Jan 28. pii: S1550-4131(19)30002-6. doi: 10.1016/j.cmet.2019.01.002. [Epub ahead of print]
NEJMAntibody-Mediated Rejection of Solid-Organ Allografts.
Lakkis FG, Chalasani G, Hariharan S.
N Eng J Med. 2018 Dec 27;379(26):2580. doi: 10.1056/NEJMc1813976.
JAMASerum Creatinine in the Critically Ill Patient With Sepsis.
Legrand M, Kellum JA.
JAMA. 2018 Dec 11;320(22):2369-2370. doi: 10.1001/jama.2018.16627.
J Clin InvestKidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted.
Tilstra JS, Avery L, Menk AV, Gordon RA, Smita S, Kane LP, Chikina M, Delgoffe GM, Shlomchik MJ.
J Clin Invest. 2018 Nov 1;128(11):4884-4897. doi: 10.1172/JCI120859. Epub 2018 Sep 24.
NEJMA Randomized Trial of a Family-Support Intervention in Intensive Care Units.
White DB, Angus DC, Shields AM, Buddadhumaruk P, Pidro C, Paner C, Chaitin E, Chang CH, Pike F, Weissfeld L, Kahn JM, Darby JM, Kowinsky A, Martin S, Arnold RM; PARTNER Investigators.
N Eng J Med. 2018 Jun 21;378(25):2365-2375. doi: 10.1056/NEJMoa1802637
NEJMMimicking Factor VIII to Manage the Factor VIII-Deficient State.
Ragni MV.
N Eng J Med. 2018 Aug 30;379(9):880-882. doi: 10.1056/NEJMe1808789
Latest Grants, $ 1 Million and Above
schenkerPI: Yael Schenker, MD, MAS, Division of General Internal Medicine
Agency: NCI
Title: Patient-centered and efficacious advance care planning in cancer: the PEACe comparative effectiveness trial
Project timeline: 03/01/2019 - 02/08/2024
Direct Costs: $2,024,302
Indirect Costs: $1,085,151
Type of Grant: R01
finkelPI: Toren Finkel, MD, PhD, Aging Institute/Division of Cardiology
Agency: NHLBI
Title: The Role of Calcium Entry Through the Mitochondrial Uniporter in Regulating Cardiac Metabolism and Physiology
Project timeline: 02/01/2019 - 01/31/2023
Direct Costs: $1,676,063
Indirect Costs: $935,676
Type of Grant: R01
jurczakPI: Michael Jurczak, PhD, Division of Endocrinology and Metabolism
Agency: NIDDK
Title: Role of Fbxo48-mediated AMPK Proteostasis in the Pathogenesis and Treatment of NAFLD
Project timeline: 01/01/2019 - 12/31/2023
Direct Costs: $1,305,480
Indirect Costs: $737,595
Type of Grant: R01
mctiguePI: Kathleen Mary McTigue, MD, MPH, MS, Division of General Internal Medicine
Agency: People-Centered Research Foundation
Title: A People-Centered Mid-Atlantic Research Network PCORNET 2.0
Project timeline: 11/01/2018 - 09/30/2020
Direct Costs: $2,573,175
Indirect Costs: $84,725
Type of Grant: RES
formanPI: Daniel Forman, MD, Division of Geriatric Medicine
Agency: NIA
Title: Modified Application of Cardiac Rehabilitation for Older Adults (MACRO)
Project timeline: 08/01/2018 - 05/31/23
Direct Costs: $4,228,066
Indirect Costs: $779,221
Type of Grant: R01
jhambPI: Manisha Jhamb, MD, MPH, Renal-Electrolyte Division
Agency: Vanderbilt University/NIDDK
Title: Population Health Management to Optimize Care for Patients with High Risk Chronic Kidney Disease
Project timeline: 08/01/2018 - 07/31/2023
Direct Costs: $2,053,818
Indirect Costs: $1,054,775
Type of Grant: R01
st hilairePI: Cynthia St. Hilaire, PhD, Division of Cardiology
Agency: NHLBI
Title: The Role of Telomerase in Calcific Aortic Valve Disease
Project timeline: 08/01/2018 - 07/31/2023
Direct Costs: $1,499,670
Indirect Costs: $824,430
Type of Grant: R01
patelPI: Sanjay Patel, MD, MS, Division of Pulmonry, Allergy and Critical Care Medicine
Agency: NHLBI
Title: Impact of Poor Sleep on Inflammation and the Adenosine Signaling Pathway in HIV Infection
Project timeline: 08/01/2018 - 04/30/2022
Direct Costs: $1,345,888
Indirect Costs: $732,329
Type of Grant: R01
jurczakPI: Michael Jurczak, PhD, Division of Endocrinology and Metabolism
Agency: NIDDK
Title: Obesity-Associated Mitophagy Resistance
Project timeline: 07/25/2018 - 05/31/2023
Direct Costs: $1,125,000
Indirect Costs: $635,625
Type of Grant: R01