Research

The University of Pittsburgh Department of Medicine is a formidable leader in cutting-edge research. Our basic scientists, clinical researchers, and clinicians work daily to make research discoveries that will positively impact the world’s healthcare.

Our numbers:

  • With 665 faculty, we are the largest department within the University of Pittsburgh School of Medicine.
  • Our NIH funding level is ranked in the top 10 nationally among other Departments of Internal Medicine.
  • The medical school’s NIH funding level ranks fifth in the nation.

Our scientists, physician-scientists, and clinicians do the advanced research that is changing people’s lives—and furthering our understanding of science. The papers they publish in high-impact journals … the grants and training awards they receive, including five new T32s in fiscal year 2015-16 … are all reflections of our investigators’ skill, dedication, and commitment.

Latest High-Impact Publications
JCI InsightUnexpected kidney-restricted role for IL-17 receptor signaling in defense against systemic Candida albicans infection.
Ramani K, Jawale CV, Verma AH, Coleman BM, Kolls JK, Biswas PS.
JCI Insight.2018 May 3;3(9). pii: 98241. doi: 10.1172/jci.insight.98241.
Nature ImmunologyIL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival.
Majumder S, Amatya N, Revu S, Jawale CV, Wu D, Rittenhouse N, Menk A, Kupul S, Du F, Raphael I, Bhattacharjee A, Siebenlist U, Hand TW, Delgoffe GM, Poholek AC, Gaffen SL, Biswas PS, McGeachy MJ.
Nat Immunol. 2019 May;20(5):534-545. doi: 10.1038/s41590-019-0367-4. Epub 2019 Apr 8.
PNASConcentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina.
Nmezi B, Xu J, Fu R, Armiger TJ, Rodriguez-Bey G, Powell JS, Ma H, Sullivan M, Tu Y, Chen NY, Young SG, Stolz DB, Dahl KN, Liu Y, Padiath QS.
Proc Natl Acad Sci U S A. 2019 Feb 14. pii: 201810070. doi: 10.1073/pnas.1810070116. [Epub ahead of print]
Cell MetabInhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by _-Catenin Mutations.
Adebayo Michael AO, Ko S, Tao J, Moghe A, Yang H, Xu M, Russell JO, Pradhan-Sundd T, Liu S, Singh S, Poddar M, Monga JS, Liu P, Oertel M, Ranganathan S, Singhi A, Rebouissou S, Zucman-Rossi J, Ribback S, Calvisi D, Qvartskhava N, Gšrg B, HŠussinger D, Chen X, Monga SP.
Cell Metab. 2019 Jan 28. pii: S1550-4131(19)30002-6. doi: 10.1016/j.cmet.2019.01.002. [Epub ahead of print]
NEJMAntibody-Mediated Rejection of Solid-Organ Allografts.
Lakkis FG, Chalasani G, Hariharan S.
N Eng J Med. 2018 Dec 27;379(26):2580. doi: 10.1056/NEJMc1813976.
JAMASerum Creatinine in the Critically Ill Patient With Sepsis.
Legrand M, Kellum JA.
JAMA. 2018 Dec 11;320(22):2369-2370. doi: 10.1001/jama.2018.16627.
J Clin InvestKidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted.
Tilstra JS, Avery L, Menk AV, Gordon RA, Smita S, Kane LP, Chikina M, Delgoffe GM, Shlomchik MJ.
J Clin Invest. 2018 Nov 1;128(11):4884-4897. doi: 10.1172/JCI120859. Epub 2018 Sep 24.
NEJMA Randomized Trial of a Family-Support Intervention in Intensive Care Units.
White DB, Angus DC, Shields AM, Buddadhumaruk P, Pidro C, Paner C, Chaitin E, Chang CH, Pike F, Weissfeld L, Kahn JM, Darby JM, Kowinsky A, Martin S, Arnold RM; PARTNER Investigators.
N Eng J Med. 2018 Jun 21;378(25):2365-2375. doi: 10.1056/NEJMoa1802637
NEJMMimicking Factor VIII to Manage the Factor VIII-Deficient State.
Ragni MV.
N Eng J Med. 2018 Aug 30;379(9):880-882. doi: 10.1056/NEJMe1808789
Latest Grants, $ 1 Million and Above
riddlerPI: Sharon Riddler, MD, Division of Infectious Diseases
Agency: NIAID
Title: Native-Like Envelope Trimer Therapeutic Vaccination for Induction of Broadly Neutralizing Antibodies to Facilitate HIV Functional Cure
Project timeline: 04/14/2020 - 03/31/2025
Direct Costs: $5,029,063
Indirect Costs: $1,352,208
Type of Grant: U01
rizzoPI: Stacey Rizzo, PhD, Aging Institute
Agency: NIA
Title: Role of Lifespan Intervention on the Regulation and Progression of Alzheimer's Disease
Project timeline: 06/01/2020 - 05/31/2025
Direct Costs: $2,802,626
Indirect Costs: $1,474,619
Type of Grant: R01
arteelPI: Gavin E. Arteel, PhD, Division of Gastroenterology, Hepatology and Nutrition
Agency: NIAAA
Title: Biomarkers of Alcoholic Hepatitis
Project timeline: 06/01/2020 - 05/31/2025
Direct Costs: $2,106,195
Indirect Costs: $895,005
Type of Grant: R01
fergusonPI: Robert Ferguson, PhD, Division of Hematology/Oncology
Agency: NCI
Title: Mobile Device CBT for Chemotherapy-Related Cognitive Dysfunction: A Multi-Center Randomized Controlled Trial
Project timeline: 06/01/2020 - 05/31/2025
Direct Costs: $531,058 (2020)
Indirect Costs: $131,700 (2020)
Type of Grant: R01
greenspanPI: Susan Greenspan, MD, Division of Geriatric Medicine
Agency: NIA
Title: Innovative Approach to Geriatric Osteoporosis
Project timeline: 06/01/2020 - 05/31/2025
Direct Costs: $1,964,034
Indirect Costs: $843,829
Type of Grant: R01
shihui liuPI: Shihui Liu, MD, PhD, Division of Cardiology
Agency: NIAID
Title: Defining Cellular Receptors for the Bacillus cereus Hemolysin BL Toxin (HBL) and the Development of Anti-HBL Therapies
Project timeline: 02/21/2020 - 01/31/2025
Direct Costs: $1,586,570
Indirect Costs: $916,911
Type of Grant: R01
stockerPI: Sean Stocker, PhD, Renal-Electrolyte Division
Agency: NHLBI
Title: Identification of Mechano Versus Chemo-Sensitive Renal Sensory Neurons in Hypertension
Project timeline: 04/01/2020 - 03/31/2024
Direct Costs: $1,515,040
Indirect Costs: $840,176
Type of Grant: R01
weiszPI: Ora Weisz, PhD, Renal-Electrolyte Division
Agency: NIDDK
Title: Endocytic Pathway Dysfunction in Dent Disease
Project timeline: 03/10/2020 - 02/28/2025
Direct Costs: $1,484,320
Indirect Costs: $858,432
Type of Grant: R01
scottPI: Iain Scott, PhD, Division of Cardiology and Vascular Medicine Institute
Agency: NHLBI
Title: Novel Strategies to Resolve Metabolic Defects in the Diabetic Heart
Project timeline: 04/01/2020 - 03/31/2024
Direct Costs: $1,224,164
Indirect Costs: $691,656
Type of Grant: R01
nyunoyaPI: Toru Nyunoya, MD, Division of Pulmonary, Allergy and Critical Care Medicine
Agency: NHLBI
Title: Role of TACC2 In Smoking-Induced COPD
Project timeline: 02/15/2020 - 01/31/2024
Direct Costs: $1,028,368
Indirect Costs: $546,816
Type of Grant: R01