Research

The University of Pittsburgh Department of Medicine is a formidable leader in cutting-edge research. Our basic scientists, clinical researchers, and clinicians work daily to make research discoveries that will positively impact the world’s healthcare.

Our numbers:

  • With 758 faculty, we are the largest department within the University of Pittsburgh School of Medicine.
  • Our NIH funding level is ranked in the top 10 nationally among other Departments of Internal Medicine.
  • The medical school’s NIH funding level ranks fifth in the nation.

Our clinicians and scientists are engaged in advanced research that is changing people’s lives and furthering our understanding of science. From papers published in high-impact journals to grants and awards received across every stage of research, all are reflections of our investigators’ skill, dedication, and commitment.

Latest High-Impact Publications
JCI InsightPDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis.
Li L, Sun F, Han L, Liu X, Xiao Y, Gregory AD, Shapiro SD, Xiao G, Qu Z.
JCI Insight. 2021 Feb 4:144394. doi: 10.1172/jci.insight.144394. Epub ahead of print. PMID: 33539325.
Science MagazineRecurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape.
McCarthy KR, Rennick LJ, Nambulli S, Robinson-McCarthy LR, Bain WG, Haidar G, Duprex WP.
Science. 2021 Feb 3:eabf6950. doi: 10.1126/science.abf6950. Epub ahead of print. PMID: 33536258.
Nat Chem BioA Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.
Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, Jiang Y, Monga SP, O'Donnell CP, Finkel T, Chen BB, Mallampalli RK.
Nat Chem Biol. 2021 Jan 25. doi: 10.1038/s41589-020-00723-0. Epub ahead of print. PMID: 33495648.
PNASThe secretome mouse provides a genetic platform to delineate tissue-specific in vivo secretion.
Liu J, Jang JY, Pirooznia M, Liu S, Finkel T.
Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2005134118. doi: 10.1073/pnas.2005134118. PMID: 33431665; PMCID: PMC7826384.
Cell Host MicrobeSequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors.
Liu J, Zuo Z, Sastalla I, Liu C, Jang JY, Sekine Y, Li Y, Pirooznia M, Leppla SH, Finkel T, Liu S.
Cell Host Microbe. 2020 Sep 9;28(3):402-410.e5. doi: 10.1016/j.chom.2020.05.012. Epub 2020 Jun 15. PMID: 32544461; PMCID: PMC7486266.
Science ImmunologyOral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis.
Aggor FEY, Break TJ, Trevejo-Nu–ez G, Whibley N, Coleman BM, Bailey RD, Kaplan DH, Naglik JR, Shan W, Shetty AC, McCracken C, Durum SK, Biswas PS, Bruno VM, Kolls JK, Lionakis MS, Gaffen SL.
Sci Immunol. 2020 Jun 5;5(48):eaba0570. doi: 10.1126/sciimmunol.aba0570. PMID: 32503875; PMCID: PMC7340112.
PNASPEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells.
Zhao J, Dar HH, Deng Y, St Croix CM, Li Z, Minami Y, Shrivastava IH, Tyurina YY, Etling E, Rosenbaum JC, Nagasaki T, Trudeau JB, Watkins SC, Bahar I, Bayõr H, VanDemark AP, Kagan VE, Wenzel SE.
Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14376-14385. doi: 10.1073/pnas.1921618117. Epub 2020 Jun 8. PMID: 32513718; PMCID: PMC7321965.
Sci Transl MedRestoring glucose uptake rescues neutrophil dysfunction and protects against systemic fungal infection in mouse models of kidney disease.
Jawale CV, Ramani K, Li DD, Coleman BM, Oberoi RS, Kupul S, Lin L, Desai JV, Delgoffe GM, Lionakis MS, Bender FH, Prokopienko AJ, Nolin TD, Gaffen SL, Biswas PS.
Sci Transl Med. 2020 Jun 17;12(548):eaay5691. doi: 10.1126/scitranslmed.aay5691. PMID: 32554707.
Nature CommunicationsSuper-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis.
Xu J, Ma H, Ma H, Jiang W, Mela CA, Duan M, Zhao S, Gao C, Hahm ER, Lardo SM, Troy K, Sun M, Pai R, Stolz DB, Zhang L, Singh S, Brand RE, Hartman DJ, Hu J, Hainer SJ, Liu Y.
Nat Commun. 2020 Apr 20;11(1):1899. doi: 10.1038/s41467-020-15718-7. PMID: 32313005; PMCID: PMC7171144.
JCI InsightIntercalated cell BK_ subunit is required for flow-induced K+ secretion.
Carrisoza-Gaytan R, Ray EC, Flores D, Marciszyn AL, Wu P, Liu L, Subramanya AR, Wang W, Sheng S, Nkashama LJ, Chen J, Jackson EK, Mutchler SM, Heja S, Kohan DE, Satlin LM, Kleyman TR.
JCI Insight. 2020 Apr 7;5(8):e130553. doi: 10.1172/jci.insight.130553. PMID: 32255763; PMCID: PMC7205426.
JAMAChanges in List Prices, Net Prices, and Discounts for Branded Drugs in the US, 2007-2018.
Hernandez I, San-Juan-Rodriguez A, Good CB, Gellad WF.
JAMA.2020 Mar 3;323(9):854-862. doi: 10.1001/jama.2020.1012. PMID: 32125403; PMCID: PMC7054846.
PLoS Biology12-h clock regulation of genetic information flow by XBP1s.
Pan Y, Ballance H, Meng H, Gonzalez N, Kim SM, Abdurehman L, York B, Chen X, Schnytzer Y, Levy O, Dacso CC, McClung CA, O'Malley BW, Liu S, Zhu B.
PLoS Biol.2020 Jan 14;18(1):e3000580. doi: 10.1371/journal.pbio.3000580. PMID: 31935211; PMCID: PMC6959563.
Latest Grants, $ 1 Million and Above
riddlerPI: Sharon Riddler, MD, Division of Infectious Diseases
Agency: NIAID
Title: Native-Like Envelope Trimer Therapeutic Vaccination for Induction of Broadly Neutralizing Antibodies to Facilitate HIV Functional Cure
Project timeline: 04/14/2020 - 03/31/2025
Direct Costs: $5,029,063
Indirect Costs: $1,352,208
Type of Grant: U01
rizzoPI: Stacey Rizzo, PhD, Aging Institute
Agency: NIA
Title: Role of Lifespan Intervention on the Regulation and Progression of Alzheimer's Disease
Project timeline: 06/01/2020 - 05/31/2025
Direct Costs: $2,802,626
Indirect Costs: $1,474,619
Type of Grant: R01
arteelPI: Gavin E. Arteel, PhD, Division of Gastroenterology, Hepatology and Nutrition
Agency: NIAAA
Title: Biomarkers of Alcoholic Hepatitis
Project timeline: 06/01/2020 - 05/31/2025
Direct Costs: $2,106,195
Indirect Costs: $895,005
Type of Grant: R01
fergusonPI: Robert Ferguson, PhD, Division of Hematology/Oncology
Agency: NCI
Title: Mobile Device CBT for Chemotherapy-Related Cognitive Dysfunction: A Multi-Center Randomized Controlled Trial
Project timeline: 06/01/2020 - 05/31/2025
Direct Costs: $531,058 (2020)
Indirect Costs: $131,700 (2020)
Type of Grant: R01
greenspanPI: Susan Greenspan, MD, Division of Geriatric Medicine
Agency: NIA
Title: Innovative Approach to Geriatric Osteoporosis
Project timeline: 06/01/2020 - 05/31/2025
Direct Costs: $1,964,034
Indirect Costs: $843,829
Type of Grant: R01
shihui liuPI: Shihui Liu, MD, PhD, Division of Cardiology
Agency: NIAID
Title: Defining Cellular Receptors for the Bacillus cereus Hemolysin BL Toxin (HBL) and the Development of Anti-HBL Therapies
Project timeline: 02/21/2020 - 01/31/2025
Direct Costs: $1,586,570
Indirect Costs: $916,911
Type of Grant: R01
stockerPI: Sean Stocker, PhD, Renal-Electrolyte Division
Agency: NHLBI
Title: Identification of Mechano Versus Chemo-Sensitive Renal Sensory Neurons in Hypertension
Project timeline: 04/01/2020 - 03/31/2024
Direct Costs: $1,515,040
Indirect Costs: $840,176
Type of Grant: R01
weiszPI: Ora Weisz, PhD, Renal-Electrolyte Division
Agency: NIDDK
Title: Endocytic Pathway Dysfunction in Dent Disease
Project timeline: 03/10/2020 - 02/28/2025
Direct Costs: $1,484,320
Indirect Costs: $858,432
Type of Grant: R01
scottPI: Iain Scott, PhD, Division of Cardiology and Vascular Medicine Institute
Agency: NHLBI
Title: Novel Strategies to Resolve Metabolic Defects in the Diabetic Heart
Project timeline: 04/01/2020 - 03/31/2024
Direct Costs: $1,224,164
Indirect Costs: $691,656
Type of Grant: R01
nyunoyaPI: Toru Nyunoya, MD, Division of Pulmonary, Allergy and Critical Care Medicine
Agency: NHLBI
Title: Role of TACC2 In Smoking-Induced COPD
Project timeline: 02/15/2020 - 01/31/2024
Direct Costs: $1,028,368
Indirect Costs: $546,816
Type of Grant: R01