The Division of Hem Onc was again strongly represented at this year’s ASCO meeting with many residents, fellows and faculty attending and presenting their recent findings. Congratulations to Dr. Manisha Bhattacharya for receiving the competitive ASCO Young Investigator Award and to Division chief Dr. Taofeek Owonikoko who has been named ASCO treasurer for 2023-24.
Dr. Jingxiao “JJ” Jin (1st year fellow) presented the study: “Interim results from a phase I/II study of duvelisib PI3Kδγ inhibitor and nivolumab in patients with advanced unresectable melanoma who have progressed on anti-PD1 therapy.” (co authors: Jingxiao Jin, Anjali Rohatgi, Andrew Gabrielle, Amy Rose, Melissa Wilson, Tullia C. Bruno, John M. M. Kirkwood)
Dr. Manisha Bhattacharya after receiving the ASCO Young Investigator Award with Division chief Dr. Taofeek Owonikoko
Dr. Xiancheng “Lewis” Wu (PGY-2 resident) reported on: “A radiomic-based predictive model of lung adenocarcinoma brain metastases and molecular subtypes” (co-authors: Xiancheng Wu, Maria A Velez, Murat Ak, Nourel Tahon, Priyadarshini Mamindla, Vishal Peddagangireddy, Rivka R. Colen, Laura P. Stabile, Timothy F. Burns)
Dr. Andrew Knight (PGY-3 resident) presented the abstract: “Prognostic significance of immune-related adverse events and immunosuppression in patients with melanoma receiving adjuvant anti-PD-1 therapy.” (Co-authors: Andrew David Knight, Lilit Karapetyan, Sabrina Bruno, Hassan Mohammed Abushukair, Na Bo, Hong Wang, Cindy Sander, John M. M. Kirkwood)
Dr. Benjamin Nacev (assistant professor) presented a talk entitled: “Integrating Genomic Profiling in the Care of Patients with Sarcoma: From Diagnosis to Therapy”.
Dr. Risa Wong (assistant professor) presented her study entitled: “Differences in real-world pembrolizumab dosing patterns (every 3 weeks versus every 6 weeks) across a large cancer center network” (Co authors: Divya Natesan, Priyanka Chablani, Hong wang, Mark Jelinek, Margaret Rosenzweig, Risa Wong)
Dr. Jason Luke (associate professor) reported on: “Pembrolizumab versus placebo as adjuvant therapy in stage IIB or IIC Melanoma: Final analysis of distant metastasis-free survival in the phase 3 KEYNOTE-716 study”
Dr. Anwaar Saeed (associate professor) contributed to the following abstracts:
- “Phase 1 dose escalation study of DSP107, a first-in-class CD47 and 4-1BB targeting fusion protein, in combination with atezolizumab in patients with advanced solid tumors.”
(Co-Authors: Anwaar Saeed, Babar Bashir, Jason J. Luke, Reuven Chantre, Shira Amsili, Rinat Tabakman, Yaffa Shwartz, Adam Foley-Comer, Antonio Jimeno)
- “A phase 2 single-arm study of berzosertib in combination with irinotecan in patients with progressive TP53 mutant gastric and gastro-esophageal junction cancer.”
(Co-Authors: Shannon Stockton, Heloisa P. Soares, Farshid Dayyani, Anwaar Saeed, Edward S. Kim, Ning Jin, George Hosni Yacoub, Jennifer Whisenant, G. Dan Ayers, Steven Gore, Satya (Nanu) Das, Jordan Berlin)
- “Phase 2 study of elraglusib (9-ING-41), a glycogen synthase kinase-3b inhibitor, in combination with gemcitabine plus nab-paclitaxel (GnP) in patients with previously untreated advanced pancreatic ductal adenocarcinoma (PDAC).”
(Co-Authors: Devalingam Mahalingam, Anwaar Saeed, Steven Francis Powell, Marisol Huerta Alvaro, Vaibhav Sahai, Andrew L. Coveler, Elizabeth J. Davis, Neeltje Steeghs, Mary Frances Mulcahy, Alexander G Raufi, Ludimila Cavalcante, Andres Cervantes, Jordan Berlin, Janna Afanasjeva, William Mikrut, Sheri Lynn Smith, Francis J. Giles, Benedito A. Carneiro)
- “STELLAR-303: A phase 3 study of XL092 in combination with atezolizumab versus regorafenib in patients with previously treated metastatic colorectal cancer.”
(Co-Authors: J. Randolph Hecht, Josep Tabernero, Aparna Raj Parikh, Yijia Wang, Zhong Wang, Martin Schwickart, Dominic Curran, Anwaar Saeed)
- “Targeting germline or somatic DNA repair defects (beyond BRCA) in pancreatic cancer with niraparib: A phase II study (NIRA-PANC).
(Co-Authors: Anup Kasi, Junqiang Dai, Raed Moh’d Taiseer Al-Rajabi, Joaquina Celebre Baranda, Anwaar Saeed, Prabhakar Chalise, Erin Carroll, Shannon Bradbury, Stephen Hyter, Malgorzata Anna Witek, Venkatadri Beeki, Richard J. McKittrick, Manidhar Reddy Lekkala, Anusha Chidharla, Sean Kumer, Timothy Schmitt, Stephen K. Williamson, Steven Soper, Andrew K. Godwin, Weijing Sun)
- “Trastuzumab-induced cardiotoxicity in breast cancer patients: A meta-analysis and review of the literature (2012-2022).
Authors: Fnu Anamika, Akshit Chitkara, Komal Saharan, Tushar Choudhary, Ujjwal Soni, Gabriella Angelina Harmon, Anwaar Saeed)