Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine

Faculty Profiles
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photo Lokesh Sharma, PhD

Pulmonary, Allergy and Critical Care Medicine

Assistant Professor of Medicine

Email: sharmalk2@upmc.edu

Phone: 412-692-2210
Contact
Office: UPMC Montefiore, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2210
Fax: 412-692-2260
E-mail: sharmalk2@upmc.edu
Administrative Assistant:
Marcus Miller
Email: millerm25@upmc.edu
Phone: 412-692-2211
Fax: 412-692-2260
Education and Training
Education
B.Pharmacy, Gyan Vihar School of Pharmacy, Jaipur, India, 2009
PhD, St. John’s University, New York, 2015
Training
Post Doctoral Associate, Yale School of Medicine, 2019
Research Interest
My research aims to identify cellular and molecular mechanisms that provide an advantage to the host by either promoting the pathogen clearance or limiting the pathogen induced tissue damage. My research aims to identify these mechanisms in settings of compromised host such as a host with viral infection or during aging process.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Chang D, Lin M, Wei L, Xie L, Zhu G, Dela Cruz CS, Sharma L. Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China. Journal of American Medical Association. 2020; 323 (11): 1092-1093.
Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, Dela Cruz CS, Wang Y, Wu C, Xiao Y, Zhang L, Han L, Dang S, Yan X, Yang QW, Xu, Zhu HD, Xu YC. Jin Q, Sharma L, Wang L, Wang J. Profiling early humoral response to diagnose novel coronavirus disease (COVID-19). Clinical Infectious Disease. 2020; 71 (15): 778-785.
De Chang, Mo G, Yuan X, Tao Y, Peng X, Wang FS, Xie L, Sharma L, Dela Cruz CS, Qin E. Time kinetics of viral clearance and resolution of symptoms in novel coronavirus infection. American Journal of Respiratory and Critical Care Medicine. 2020; 201 (9): 1150-1152.
Walz L, Cohen AJ, Rebaza AP, Vanchieri J, Slade MD, Dela Cruz CS, Sharma L. JAK-inhibitor and type I interferon ability to produce favorable clinical outcomes in COVID-19 patients: a systematic review and meta-analysis. BMC Infectious Diseases. 2021; 21(1): 1-10.
Peng X, Kim J, Gupta G, Agaronyan K, Mankowski MC, Korde A, Takyar SS, Shin HJ, Habet V, Voth S, Audia JP, Chang D, Liu X, Wang L, Cai Y, Tian X, Ishibe S, Kang MJ, Compton S, Wilen CB, Dela Cruz CS, Sharma L. Coronavirus lung infection impairs host immunity against secondary bacterial infection by promoting lysosomal dysfunction. Journal of Immunology. 2022; 209(7): 1314-1322.
Chang D, Zhao P, Zhang D, Dong JH, Xu z, Yang G, Li by, Liu HX, Li B, Qin CF, Peng X, Wang F, Xie L, Chen Z, Dela Cruz CS, Sharma L, Qin EQ. Persistent viral presence determines the clinical course of the disease in COVID-19. The Journal of Allergy and Clinical Immunology: In Practice. 2020; 8(8): 2585-2591.
Chang D, Lin M, Song N, Zhu Z, Gao J, Li S, Liu H, Liu DZ, Zhang Y, Sun W, Zhou X, Yang B, Li Y, Wang L, Xiao Z, Li K, Xing L, Xie L, Sharma L. The emergence of influenza B as a major respiratory pathogen in the absence of COVID-19 during the 2021–2022 flu season in China. Virology Journal. 2023; 20(1): 1-10.
Najjar-Debbiny R, Barnett-Griness O, Khoury J, Gronich N, Weber G, Adir Y, Shteinberg M, Shneir S, Sharma L, Saliba W. Association between COVID-19 infection and pulmonary fibrosis: a nested case-control study. The American Journal of Medicine. 2023.
Sharma L, Peng X, Qing H, Hillard BK, Kim J, Swaminathan A, Tian J, Israni-Winger K, Zhang C, Habet V, Wang L, Gupta G, Tian X, Ma Y, Shin HJ, Kang MJ, Ishibe S, Young L H, Kotenko, Compton S, Wilen CB, Wang A, Dela Cruz CS. Distinct roles of type I and type III interferons during a native murine ß coronavirus lung infection. Journal of Virology. 2022; 96(2): e01241-21.
Xie C, Li Q, Li L, Peng X, Ling Z, Xiao B, Feng J, Chen Z, Chang D, Xie L, Dela Cruz CS, Sharma L. Association of early inflammation with age and asymptomatic disease in COVID-19. Journal of Inflammation Research. 2021; 1207-1216.
Notable Achievements
Rising Star, Pulmonary Infections and Tuberculosis Assembly, American Thoracic Society, 2020
American Lung Association Study Section, 2018-2022
Parker B Francis Fellowship, 2020

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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