- Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells. In allogeneic hematopoietic stem cell transplantation, donor αβ T cells attack recipient tissues, causing graft-versus-host disease (GVHD), a major cause of morbidity and mortality. A central question has been how GVHD is sustained despite T cell exhaustion from chronic antigen stimulation. The current model for GVHD holds that disease is maintained through the continued recruitment of alloreactive effectors from blood into affected tissues. Here, the authors show, using multiple approaches including parabiosis of mice with GVHD, that GVHD is instead primarily maintained locally within diseased tissues. By tracking 1,203 alloreactive T cell clones, a mathematical model was fitted, predicting that within each tissue a small number of progenitor T cells maintain a larger effector pool. Consistent with this, Dr. Warren Shlomchik et al identified a tissue-resident TCF-1+ subpopulation that preferentially engrafted, expanded, and differentiated into effectors upon adoptive transfer. These results suggest that therapies targeting affected tissues and progenitor T cells within them would be effective. (Sacirbegovic F, …, Shlomchik WD. Immunity. 2023 Feb 14;56(2):369-385.e6. PMID: 36720219.)
- Dr. Samit Ghosh (PI), “Renal endothelium and the development of chronic kidney disease in sickle cell disorders,” NIDDK R01. Read more
- Dr. Dan Zandberg / Dr. Theresa Whiteside / Dr. Brenda Diergaarde (MPI), “Small extracellular vesicles as biomarkers of prognosis and response to therapy in head and neck cancer,” NIDCR R01
- 2023 AACR annual meeting, Orlando FL:
- Dr. Taofeek Owonikoko will chair the session: “Small Cell Lung Cancer: Moving Biology to the Clinic” and present the talk titled: Putting SCLC in context using emerging clinical and translational insights.
- Dr. Nadine Hempel will chair the session: “Tumor Cell Adaptability and Stress Response” and present the talk titled: “ Oxidative stress adaptations during metastasis: Focus on antioxidant enzyme function and regulation”.
- Dr. Lan Coffman will chair the session: Models for Aging and Cancer and present the talk titled: “Studying the impact of the aging stromal microenvironment on cancer initiation”