
Laboratories
Chen LabDr. Chen’s primary research interest is in the study of molecular mechanisms controlling inflammation and cell proliferation via protein ubiquitination. Dr. Chen’s second area of research interest is small molecule drug design. He has successfully designed and synthesized a novel series of first-in-class small molecule FBXO3 protein inhibitors. His long-term goal is to develop a new class of therapeutics to combat inflammatory diseases focusing on a novel mechanism. | Lab Website |
Beibei (Bill) Chen, PhD |
Corcoran LabDr. Corcoran’s research focuses include the development of inhaled medications and aerosol-based nuclear imaging of the lungs. This includes measurements of mucociliary clearance and airway surface liquid absorption in adult and pediatric cystic fibrosis patients. These techniques have also been applied in other patients groups including asthma, congenital heart disease, and muscular dystrophy patients. He has active collaborations with the Department of Physics at Carnegie Mellon University to design self-dispersing aerosol drugs and the Chemical Engineering Department at Pitt to develop computer models of liquid and ion transport across the airway epithelium. |
Tim Corcoran, PhD |
Gladwin LabDr. Gladwin’s clinical research and expertise focuses on pulmonary hypertension and pulmonary complications of sickle cell disease. Since 1998, Dr. Gladwin’s research has led to four scientific discoveries: 1) the nitrite anion is a circulating storage pool for NO bioactivity that regulates hypoxic vasodilation and the cellular resilience to low oxygen and ischemia; 2) a novel physiological function for hemoglobin as an electronically- and allosterically-regulated nitrite reductase; 3) the characterization of a novel mechanism of disease, hemolysis-associated endothelial dysfunction; and 4) the mechanistic, clinical, and epidemiological description of a human disease syndrome, hemolysis-associated pulmonary hypertension. |
Mark Gladwin, MD |
Kass LabDaniel J Kass, MD is the Director, Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases and a clinician scientist who specializes in the care of patients with interstitial lung disease (ILD), and, particularly, idiopathic pulmonary fibrosis (IPF). Because IPF is currently untreatable, his research has focused on identifying novel and personalized therapies for patients who suffer from IPF, using two distinct aspects of the biology of fibroblasts—the principal effectors of pulmonary fibrosis: how fibroblasts interact with the immune system to regulate inflammation in pulmonary fibrosis and how the endogenous hormone relaxin may regulate the differentiation of fibroblasts into the highly active scarring cells known as myofibroblasts. |
Daniel Kass, MD |
Lee LabBroadly speaking, Dr. Lee studies host susceptibility to lung injury and the role of phagocytes that orchestrate and participate in the injury response as well as aid in the repair and resolution of inflammation. Utilizing a repertoire of relevant injury models including bacterial pneumonia, sterile LPS-induced lung injury, chronic cigarette smoke exposure and RBC transfusion, she studies innate immune activation signals triggered during lung inflammation and subsequent de-activation signals requisite for appropriate resolution. |
Janet S. Lee, MD |
McDyer LabAs Director of the Lung Transplantation Translational Research Program, Dr. McDyer is keenly interested in the mechanisms of tolerance and rejection, host defense and ischemic reperfusion injury. Using the mouse orthotopic lung transplant model and the heterotopic tracheal transplant model, he specifically addresses the regulation of cytokine responses in rejection and how different cytokine milieus lead to variable rejection pathology. Dr. McDyer also studies the immune mechanisms of ischemic reperfusion injury in the mouse orthotopic lung transplant model and using human PBMC subjected to in vitro hypoxia. |
John McDyer, MD |
Morris LabThe type of studies performed by Dr. Morris’ group include large cohort epidemiologic studies of lung disease and respiratory symptoms, translational studies in which physiologic and molecular techniques are applied to patient populations, and collaborations with co-investigators utilizing non-human primate models of disease. Dr. Morris’ research interests focus in several overlapping areas including HIV-associated lung disease, HIV-associated emphysema, and the role of Pneumocystis in COPD. |
Alison Morris, MD, MS |
Myerberg LabDr. Myerburg’s primary research interest is to determine the mechanisms and pathological conditions associated with hydration of the airway lumen. His research uses in vitro and in vivo techniques to understand the ion transport proteins involved in maintain optimal airway surface liquid volume in health and how alterations in these processes results in dysfunctional mucuociliary clearance from the lung in cystic fibrosis, asthma, and related airway diseases. |
Michael Myerberg, MD |
O’Donnell LabDr. O’Donnell’s interests are in the pathophysiology of hypoxia and sleep apnea and its relationship to metabolic and cardiovascular dysfunction. His laboratory utilizes murine models of obesity and hypoxia using a variety of chronically instrumented inbred and transgenic mouse strains. |
Christopher O’Donnell, PhD |
Pilewski LabCo-director of the Adult Cystic Fibrosis program at UPMC, Dr. Pilewski’s research centers on Cystic Fibrosis and other suppurative lung diseases, both pre- and post-transplant. He works towards improving post‐transplant outcomes particularly in this patient population, including in patients who are colonized with drug resistant organisms. He also serves as principal investigator of a lung tissue bank that makes explanted lung samples available to investigators studying Cystic Fibrosis and other end stage lung diseases. Lastly, he is collaborating with Dr. Andrej Petrov on studies of hypogammaglobulinemia in lung transplant recipients |
Joseph Pilewski, MD |
A. Ray LabThe primary goal of Dr. Ray’s research is to understand immune mechanisms involving interactions between dendritic cells (DCs), T helper cells and T regulatory cells as they relate to the regulation of chronic inflammatory diseases in the lung and the gut such as asthma and inflammatory bowel disease. She is also interested in mucosal defense mechanisms against infectious agents. All studies in her laboratory employ genetically altered mice and various immunological, molecular, biochemical and imaging techniques. |
Anuradha Ray, PhD |
P. Ray LabOngoing research in Dr. Ray’s laboratory encompasses two major areas, which are studies of innate immune mechanisms that mediate resolution of lung inflammation and protect from lung injury after pneumonia and the impact of early life viral infections on immunoregulatory mechanisms in the lung. He is particularly interested in differences in host defense mechanisms between newborns and older adults that causes increased susceptibility to respiratory viruses in early rather than in later life. |
Prabir Ray, PhD |
Sundd LabDr. Sundd’s research focuses on the mechanisms of leukocyte rolling and arrest during inflammation; the role of neutrophils in pulmonary vaso-occlusion during sickle cell disease Acute Chest Syndrome; and identifying molecular mechanism of vaso-occlusion in SCD (SS) patient blood. |
Prithu Sundd, PhD |
Zhang LabDr. Zhang is interested in the molecular and genetic basis of IPF, COPD and other lung diseases. Her research is focused on the identification of both genes and peripheral biomarkers associated with the development of IPF and COPD and/or associated with the disease progression/outcome of these patients. Her laboratory is also conducting research to dissect the genetic basis of disease biomarkers for IPF and COPD. She directs the Translational Research Core Lab that is responsible for the sample processing/banking and peripheral biomarker analysis. |
Yingze Zhang, PhD |
ACUTE LUNG INJURY
Janet Lee, MD
Jonathan Alder, PhD
Bill Chen, PhD
Kong Chen, PhD
Michael Donahoe, MD
John Evankovich, MD
Georgios Kitsios, MD, PhD
Bryan McVerry, MD
Christopher O’Donnell, PhD
Prabir Ray, PhD
Keven Robinson, MD
Faraaz Shah, MD, MPH
Tomeka Suber, MD, PhD
Chunbin Zou, MD, PhD
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ASTHMA, ALLERGY, AND IMMUNOLOGY
Sally Wenzel, MD
Juan Celedon, MD, DrPH
Merritt Fajt, MD
Andrej Petrov, MD
Anuradha Ray, PhD
Prabir Ray, PhD
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CYSTIC FIBROSIS, TRANSPLANT, AND IMMUNOLOGY
Joseph Pilewski, MD
John McDyer, MD
Tim Corcoran, PhD
Matthew Morrell, MD
Mike Myerberg, MD
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EMPHYSEMA / COPD
Frank Sciurba, MD
Jessica Bon, MD
Seyed Mehdi Nouraie, MD, PhD
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HIV LUNG RESEARCH
Alison Morris, MD, MS
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HOST DEFENSE
Prabir Ray, PhD
John Alcorn, PhD
Jen Bomberger, PhD
Janet Lee, MD
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INTERSTITIAL LUNG DISEASE
Kevin Gibson, MD
Daniel Kass, MD
Toru Nyunoya, MD
Yingze Zhang, PhD
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SLEEP
Sanjay Patel, MD, MS
Charles Atwood, MD
Chris O’Donnell, PhD
Patrick Strollo, MD
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PULMONARY HYPERTENSION / VASCULAR MEDICINE
Mark Gladwin, MD
Prithu Sundd, PhD
Division of PACCM
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Patient Care and Referral
Comprehensive Lung Center (CLC)
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