Over the past decade, addiction medicine has shifted from a misunderstood field into one where remarkable strides have been made towards understanding addiction and developing effective strategies for its prevention and treatment. At the forefront of this transformation is the Section of Treatment, Research, and Education in Addiction Medicine (STREAM) in the Division of General Internal Medicine, where investigators are helping lead that transformation through new scientific advances, deeper community engagement, and an urgent need to translate evidence into real-world impact.