Bernard J.C. Macatangay, MD, and Sanjay Patel, MD, have been awarded funding of $2,078,217 for a four-year grant by the National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) entitled “Impact of Poor Sleep on Inflammation and the Adenosine Signaling Pathway in HIV Infection”. This proposal was submitted in response to the competitive NIH funding opportunity entitled Sleep Health and Circadian Biology in HIV-Related Comorbidities (R01) under funding opportunity number RFA-HL-18-005.

This study will evaluate whether poor sleep by altering adenosine signaling may contribute to increased inflammation among people living with HIV. This may help explain how poor sleep contributes to the accelerated heart and lung disease observed among people living with HIV and offer an opportunity to reduce this risk.