Division of

Cardiology

Laboratories

AL GHOULEH LAB

Dr. Al Ghouleh’s lab is focused on the study of pulmonary hypertension, with a major focus on defining the mechanisms that underlie right ventricular phenotypic changes in this disease.

Imad al Ghouleh, PhD 
Principal Investigator

BRUEMMER LAB

Dr. Bruemmer’s current research focuses on transcriptional mechanisms by which common cardiovascular risk factors including diabetes, obesity, and inflammation activate vascular gene expression programs leading the development of atherosclerosis and restenosis.

Dennis Bruemmer, MD, PhD
Principal Investigator

CHAN LAB

Dr Chan’s lab studies the molecular mechanisms of pulmonary vascular disease and pulmonary hypertension (PH). Ongoing projects include: 1) Defining the network biology of non-coding RNAs in pulmonary hypertension, 2) Studying the molecular regulation of mitochondrial metabolism by microRNAs, and 3) Defining the regulation of circulating microRNAs in hypoxia and exercise.

Stephen Y. Chan, MD, PhD
Principal Investigator

DUTTA LAB

Dr. Dutta’s laboratory studies 1) the role of inflammation in cardiovascular diseases, and 2) activation of hematopoietic stem cells after myocardial infarction.

Partha Dutta, DVM, PhD
Principal Investigator

GLADWIN LAB

Dr. Gladwin’s clinical research and expertise focuses on pulmonary hypertension and pulmonary complications of sickle cell disease.  Since 1998, Dr. Gladwin’s research has led to four scientific discoveries: 1) the nitrite anion is a circulating storage pool for NO bioactivity that regulates hypoxic vasodilation and the cellular resilience to low oxygen and ischemia; 2) a novel physiological function for hemoglobin as an electronically- and allosterically-regulated nitrite reductase; 3) the characterization of a novel mechanism of disease, hemolysis-associated endothelial dysfunction; and 4) the mechanistic, clinical, and epidemiological description of a human disease syndrome, hemolysis-associated pulmonary hypertension.

Mark T. Gladwin, MD
Principal Investigator

GOMEZ LAB

The Gomez lab is focused on studying the functional role of epigenetic and transcriptional mechanisms in controlling key properties of vascular smooth muscle cells (SMC) including cell differentiation, lineage memory and plasticity in the context of major cardiovascular diseases including atherosclerosis.

Delphine Gomez, PhD 
Principal Investigator

KAUFMAN LAB

The major research goals of the Kaufman Lab are 1) to define the biochemical events responsible for the maintenance of mtDNA content, 2) to understand how distinct pathways influence mtDNA maintenance, and 3) to understand mechanisms of mtDNA damage and resistance to damage in the context of disease.

Brett A. Kaufman, PhD
Principal Investigator

KIM LAB

The Multi-modality Biomedical Ultrasound Imaging Lab led by Dr. Kang Kim develops ultrasound-based technologies that can non-invasively image structural, mechanical, compositional, and functional features of biological tissues.

Kang Kim, MD
Principal Investigator

SABA LAB

Dr. Saba’s research broadly focuses on examining patient outcomes in patients suffering from arrhythmic conditions. More specifically, his laboratory has concentrated its efforts over the past few years on studying the causes of racial and gender disparities in the delivery of defibrillator therapy and on evaluating interventions to reduce and eliminate these disparities.

Samir Saba, MD
Principal Investigator

SALAMA LAB

A central goal of Dr. Salama’s laboratory is to elucidate the mechanisms responsible for the initiation and termination of cardiac arrhythmias.

Guy Salama, PhD
Principal Investigator

SIMON LAB

Dr. Simon’s current research interests include the study of right ventricular structural and functional adaptation to pressure overload in pulmonary hypertension and heart failure.

Marc Simon, MD, MS
Principal Investigator

ST. HILAIRE LAB

Dr. St. Hilaire’s research aims to characterize novel mechanisms regulating vascular calcification and vessel remodeling, and incorporates cell biology, signal transduction, and in vivo models. Particular research angles include the role of mechanical stress, extracellular matrix remodeling, and cellular stress response, in a variety of vascular disease contexts.

Cynthia St. Hilaire, PhD 
Principal Investigator

VILLANUEVA LAB

Dr. St. Hilaire’s research aims to characterize novel mechanisms regulating vascular calcification and vessel remodeling, and incorporates cell biology, signal transduction, and in vivo models. Particular research angles include the role of mechanical stress, extracellular matrix remodeling, and cellular stress response, in a variety of vascular disease contexts.

Liza Villanueva, MD
Principal Investigator

ELECTROPHYSIOLOGY

Samir Saba, MD
Guy Salama, PhD
Norman Wang, MD

HEART FAILURE

Michael Mathier, MD
Dennis McNamara, MD
Ravi Ramani, MD

IMAGING AND ULTRASOUND

João Cavalcante, MD
Xucai Chen, PhD
Carolyn Johnson, PhD
Kang Kim, PhD
John Pacella, MD
Prem Soman, MD
Liza Villanueva, MD
François Yu, PhD

BIOENERGETICS AND MITOCHONDRIA

Stephen Chan, MD, PhD
Brett Kaufman, PhD
Iain Scott, PhD

PULMONARY
HYPERTENSION

Imad al Ghouleh, PhD
Stephen Chan, MD, PhD
Partha Dutta, DVM, PhD
Mark Gladwin, MD
Michael Mathier, MD
Marc Simon, MD

VASCULAR BIOLOGY

Dennis Bruemmer, MD, PhD
Delphine Gomez, PhD
Cynthia St. Hilaire, PhD

For more labs studying vascular biology, please visit the Vascular Medicine Institute website.

Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute

Pitt’s Vascular Medicine Institute (VMI) expanded into cardiovascular medicine, partnering with the HVI to create the Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute. The institute harnesses an inter-disciplinary team of researchers, physicians, and physician-scientists to fulfill its mission to perform rigorous, cutting-edge basic and translational research, and train the next generation of scientists.

Dr. Joon Lee and Dr. Mark Gladwin introduce the Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute.
Division of Cardiology Academic Offices

Scaife Hall, 5th Floor
3550 Terrace Street
Pittsburgh, PA 15213
412-647-8333 | 412-647-3429 | email

Heart and Vascular Institute (HVI)

For Patients: 1-855-UPMC-HVI  (876-2484)
HeartAndVascular@upmc.edu  |  website

For Physicians: 1-866-884-8579  |  412-692-2400
MedCall: 412-647-7000  |  1-800-544-2500