Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine

Faculty Profiles
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photo Harinath Bahudhanapati, PhD, MSc

Pulmonary, Allergy and Critical Care Medicine

Research Assistant Professor of Medicine

Email: hab98@pitt.edu

Phone: 412-692-2210
Contact
Office: UPMC Montefiore, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2210
Fax: 412-692-2260
E-mail: hab98@pitt.edu
Administrative Assistant:
Stacie Truszkowski
Email: truszkowskisl@upmc.edu
Phone: 412-624-7225
Fax: 412-624-1670
Education and Training
Education
BS, Chemistry, S.K. University, India, 1999
M.Sc, University of Hyderabad, India, 2001
PhD, Schmidt College of Medicine, Florida Atlantic University, 2010
Research Interest
My research is focused on fibroblast biology in Idiopathic Pulmonary Fibrosis (IPF) at the Simmons Center for ILD. Particularly, I am interested in mechanism of action of IL8-family chemokine ‘CXCL6’ and its receptors CXCR1/2 that underlie IPF. Other interests include the role of TWIST1 in IPF and the role of GDF15 in GFRAL-independent mechanisms in the injury of the lung and liver.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Bahudhanapati H, Tan J, Jäger B, Li X, Sullivan D, Sembrat J, Rojas M, Valenzi E, Lafyatis R, Jawale C, Biswas P, Tedrow J, Königshoff M, Kaminski N, Wuyts W, Alder J, Zhang Y, Nouraie SM, Prasse A, Kass DJ. Elevated levels of CXCL6 drive matrix expression and correlate with markers of poor outcome in IPF. Eur Respir J. 2021.
Valenzi E, Bahudhanapati H, Tan J, Tabib T, Sullivan DI, Sembrat J, Fan L, Chen K, Rojas M, Lafargue A, Felsher DW, Tran PT, Kass DJ, Lafyatis R. Single-Nucleus Chromatin Accessibility Identifies a Critical Role for TWIST1 in IPF Myofibroblast Activity. Eur Respir J. 2023; May 4;2200474.
Xie B, Murali A, Vandevender AM, Chen J, Silva AG, Bello FM, Chuan B, Bahudhanapati H, Sipula I, Dedousis N, Shah FA, O'Donnell CP, Alder JK, Jurczak MJ. Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice. ISCIENCE. 2022; 25(12): 105569.
Chandrasekera, P, Perfetto M, Zhuo M, Lu C, Bahudhanapati H, Chen WC, Kulkarni P, Liu J, Yien YY, Li J, Yu C, Wei S. ADAM9 cleaves ephrin-Bs and differentially regulates Wnt and mTOR signaling downstream of Akt in colorectal cancer cells. J. Biol. Chem. 2022; June 30: 102225.
Chen TY, Li X, Goobie GC, Hung CH, Hung TK, Hamilton K, Bahudhanapati H, Tan J, Kass DJ, Zhang Y. Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1. PLoS One. 2021; Dec 31;16(12): e0254466.
Bahudhanapati H, Tan J, Dutta JA, Strock SB, Sembrat J, Àlvarez D, Rojas M, Jäger B, Prasse A, Zhang Y, Kass DJ. MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with Idiopathic Pulmonary Fibrosis. J. Biol. Chem. 2019; 294(13): 5008–5022.
Li J, Perfetto M, Neuner R, Bahudhanapati H, Christian L, Mathavan K, Bridges LC, Alfandari D, Wei S. Xenopus ADAM19 regulates Wnt signaling and neural crest specification through nonproteolytic stabilization of ADAM13. Development. 2018; Apr 4;145(7): pii:dev158154.
Bahudhanapati H, Bhattacharya S, Wei S. Evolution of vertebrate Adam genes; duplication of testicular Adams from ancient Adam9/9-like loci. PLoS One. 2015; Aug 26;10(8): e0136281.
Bahudhanapati H, Zhang Y, Sidhu SS, Brew K. Phage display of Tissue Inhibitor of Metalloproteinase-2 (TIMP-2): Identification of selective inhibitors of Collagenase-1 (MMP-1). J Biol Chem. 2011; 286(36): 31761-70.
Hamze AB, Wei S, Bahudhanapati H, Kota S, Acharya KR, Brew K. Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors. Protein Sci. 2007; 16: 1905-1913.

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
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3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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